HCID 21436737, Verbindung → HCID 21436740, Verbindung

HRID 2397925Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2397925
[Br-:1].[N+:2]([C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][N+:9]([CH2:15][CH2:16][CH3:17])=[CH:10]2)([O-])=O>CO.[Pt]=O>[BrH:1].[NH2:2][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][N:9]([CH2:15][CH2:16][CH3:17])[CH2:10]2

Komponenten

4

Edukt 1

HCID 21436737HCID 21436737, Verbindung

Produkt 1

HCID 21436740HCID 21436740, VerbindungAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

5-Nitro-2-n-propylisoquinolinium bromide (8.2 g) was dissolved in methanol (150 ml) and the solution hydrogenated over platinum oxide (0.6 g) at 45 psi. When the hydrogenation was complete, the catalyst was removed by filtration and the solvent removed in vacuo to leave a light orange solid residue of 5-amino-2-n-propyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (7.5 g). This residue was recrystallized from ethanol and the product obtained as pale orange crystals, m.p. 238°-239.5° C.

Aufarbeitung

  1. customthe catalyst was removed by filtration
  2. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cceff6d68eeb4094a9558e8d4d59a204
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04022900

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