1,2-Oxathiolane, 3-methyl-, 2,2-dioxide → HCID 59771573, Verbindung

HRID 239793

Reaktionsgleichung

Reaktionsgleichung von HRID 239793
[CH2:1]1[CH:5]2[CH2:6][CH:7]([NH2:8])[CH:3]([CH2:4]2)[CH2:2]1.[CH3:9][CH:10]1[S:14](=[O:16])(=[O:15])[O:13][CH2:12][CH2:11]1>O1CCCC1>[CH:3]12[CH2:4][CH:5]([CH2:1][CH2:2]1)[CH2:6][CH:7]2[NH:8][CH2:12][CH2:11][CH:10]([S:14]([OH:16])(=[O:15])=[O:13])[CH3:9]

Komponenten

4

Edukt 2

HCID 707161,2-Oxathiolane, 3-methyl-, 2,2-dioxideHCID 98480Exo-2-bornanamine

Produkt 1

HCID 59771573HCID 59771573, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of exo-2-aminonorbornane (1.0 g, 9.0 mmol) in tetrahydrofuran (THF, 10 mL) was added 2,4-butane sultone (1.28 g, 9.3 mmol). The solution was stirred at reflux for 3 hours. The reaction was cooled to room temperature. The solid was collected by filtration, washed with THF (2×20 mL) and dried in vacuo. 1H NMR (DMSO, 500 MHz) δ ppm 8.43 (s (broad), 1H), 2.96 (m, 3H), 2.62 (m, 1H), 2.38 (m, 1H), 2.28, (m, 1H), 1.91 (m, 1H), 1.82 (m, 1H), 1.61 (m, 1H), 1.54 (m, 2H), 1.42 (m, 2H), 1.12 (m, 6H). 13C (DMSO, 125 MHz) δ ppm 60.92, 60.79, 53.61, 53.21, 44.55, 44.36, 39.80, 39.55, 36.27, 36.15, 36.11, 35.98, 35.19, 35.13, 29.62, 29.43, 28.07, 26.88, 17.56, 14.11. ES-MS 248 (M+1).

Aufarbeitung

  1. temperatureat reflux for 3 hours
  2. filtrationThe solid was collected by filtration
  3. washwashed with THF (2×20 mL)
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-45b730f9ad5b4cf39f54939210a94f65
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642801B2

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