Dimethylamine → 4-(Dimethylamino)butane-2-sulfonic acid

HRID 239794

Reaktionsgleichung

Reaktionsgleichung von HRID 239794
[CH3:1][CH:2]1[S:6](=[O:8])(=[O:7])[O:5][CH2:4][CH2:3]1.[CH3:9][NH:10][CH3:11]>>[CH3:9][N:10]([CH3:11])[CH2:4][CH2:3][CH:2]([S:6]([OH:5])(=[O:8])=[O:7])[CH3:1]

Komponenten

3

Edukt 2

HCID 674DimethylamineHCID 707161,2-Oxathiolane, 3-methyl-, 2,2-dioxide

Produkt 1

HCID 587946244-(Dimethylamino)butane-2-sulfonic acid

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

2,4-butanesultone (1.27 g, 8.9 mmol) was added to an ice-chilled solution of dimethylamine (40% w/w in water). The solution was stirred at 0° C. for 4 hours. The solvent was evaporated in vacuo until complete dryness. The solid was washed with acetone (50 mL), collected by filtration and dried in vacuo. 1H NMR (D2O, 500 MHz) δ ppm 3.18 (t, 2H, J=8.1 Hz), 2.85 (m, 1H), 2.76 (s, 6H), 2.09 (m, 1H), 1.81 (m, 1H), 1.17 (d, 3H, J=7.3 Hz). 13C (D2O, 125 MHz) δ ppm 55.65, 53.05, 42.88, 26.72, 14.81. ES-MS182a (M+1).

Aufarbeitung

  1. customThe solvent was evaporated in vacuo until complete dryness
  2. washThe solid was washed with acetone (50 mL)
  3. filtrationcollected by filtration
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-114e0e33c64c4fbda180f55083797151
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642801B2

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