2-Iodobenzoyl chloride → 2-Iodo-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzene-1-carboximidic acid
Reaktionsgleichung
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[I:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17]>>[I:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]([NH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2)=[O:17]Komponenten
3
Versuchsvorschrift
5-Amino-2-methyl-1,2,3,4-tetrahydroisoquinoline was reacted with 2-iodobenzoyl chloride according to the procedure of Example 19 to yield 5-(2-iodobenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline; m.p. 215°-216.5° C. after purification from methanol.
Quellen und Nachweise
- ORD-Eintrag
- ord-cbfa98e359de46aaa9e593f3a0295317
- Quelldatensatz
- uspto-grants-1977_05