Sodium Bicarbonate → 1alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

HRID 2397973Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2397973
[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][O:22]C(=O)CC)[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+]>CO>[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][OH:22])[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3]

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 705838891alpha-Methyl-4-androstene-17beta,19-diol dipropionate

Produkt 1

HCID 705847651alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1α-Methyl-4-androstene-17β,19-diol dipropionate is dissolved in a 10% aqueous methanol solution and one equivalent of sodium bicarbonate is added. The solution is stirred and heated at its reflux temperature for one hour and poured onto ice water with vigorous stirring. The precipitate is removed by filtration, air dried and crystallized from hexane to yield 1α-methyl-4-androstene-17β,19-diol 17-propionate.

Aufarbeitung

  1. additionis added
  2. temperatureheated at its
  3. temperaturereflux temperature for one hour
  4. additionpoured onto ice water with vigorous stirring
  5. customThe precipitate is removed by filtration, air
  6. customdried
  7. customcrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-058026ca909142dd97a15bf7314057cc
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04022769

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