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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 2399172Erstellt: 25. Oktober 2026

Benzene, (2-chloroethoxy)- → Phenoxyethyl-norfentanyl

https://huagongshe.com/reaction/2399172

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktBenzene, (2-chloroethoxy)-HCID 12156—
Edukt4-(N-Propionylaniline)piperidineHCID 259381—
ProduktPhenoxyethyl-norfentanylHCID 5400539498,6%

Reaktionsschritte

By condensing 14.7 g 4-(N'-phenyl-N'-propionylamino)-piperidine and 19.9 g phenoxyethyl chloride, they are obtained after 24 hours reflux 22 g of the title product which after recrystallization from hot cyclohexane gives a first crop weighing 13.5 g. The pure compound melts at 100°-102°. It is soluble in hydrochloric acid. The solution after distillation leads to the recovery of the hydrochloride. The hydrochloride is soluble in water.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS04027028
Quelldatensatzuspto-grants-1977_05
ORD IDord-06dc97e744cf48a0a7842a8396006747
Quellennotizuspto-grants-1977_05