Sodium Cyanide → HCID 18973689, Verbindung

HRID 2399414Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2399414
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9]Cl)[CH2:3][CH2:2]1.[C-:18]#[N:19].[Na+]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH2:9][C:18]#[N:19])[CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 8929Sodium CyanideHCID 18973686HCID 18973686, Verbindung

Produkt 1

HCID 18973689HCID 18973689, VerbindungAusbeute 95,7 %

Versuchsvorschrift

To 3-cyclopropylmethoxy-4-difluoromethoxybenzyl chloride (26 g) in dimethylflormamide (150 mL) under an argon atmosphere was added sodium cyanide (9.7 g, 198 mmol). The resulting mixture was stirred at room temperature and heated gently for 2 h, then cooled and concentrated. The mixture was partitioned between basic brine and ether and extracted twice. The organic extract was washed with brine and was dried (sodium sulfate). The solvent was removed in vacuo to provide an orange-brown oil (24 g), which was used without purification.

Aufarbeitung

  1. temperatureheated gently for 2 h
  2. temperaturecooled
  3. concentrationconcentrated
  4. customThe mixture was partitioned between basic brine and ether
  5. extractionextracted twice
  6. extractionThe organic extract
  7. washwas washed with brine
  8. dry with materialwas dried (sodium sulfate)
  9. customThe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a1dbcaa1f8484773b9b4c71d9207d02b
Quelldatensatz
uspto-grants-1995_09
Patentnummer
US05449686

Notizen zur Reaktion

Wird geladen…