Ammonia → 2-Chloro-5-methoxypyrimidin-4-amine

HRID 2400339Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2400339
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([O:9][CH3:10])=[CH:4][N:3]=1.[NH3:11]>CO>[Cl:1][C:2]1[N:7]=[C:6]([NH2:11])[C:5]([O:9][CH3:10])=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 6014012,4-Dichloro-5-methoxypyrimidine

Produkt 1

HCID 569495382-Chloro-5-methoxypyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 2,4 dichloro-5-methoxypyrimidine (0.45 g, 2.5 mmol) and ammonia in methanol (2N, 20 ml) was stirred at room temperature overnight. The mixture was then concentrated in vacuo and washed with water. The residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether) to furnish the title compound as a white solid (211 mg). MS: [M+H]+=160

Aufarbeitung

  1. concentrationThe mixture was then concentrated in vacuo
  2. washwashed with water
  3. customThe residue was purified by column chromatography (20-60% ethyl acetate/petroleum ether)

Quellen und Nachweise

ORD-Eintrag
ord-e3a34c5197bd42178377e0d632b1b333
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796244B2

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