2,2-Dimethyl-1,3-dioxane-4,6-dione → 6-Iodo-3-carboxy-coumarin

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

5-iodosalicylaldehyde (344.2 mg, 1.39 mmol) and Meldrum's acid (200 mg, 1.39 mmol) were combined in H2O (2 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 302.0 mg of 6-iodo-3-carboxy-coumarin in 69% yield.

Herkunft & Nachweise