1351570-69-8 → 5-Bromo-4-fluoro-1H-indazole

HRID 2400943Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2400943
[Br:1][C:2]1[C:3]([F:14])=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7](C(=O)C)[N:6]=[CH:5]2>Cl.CO>[Br:1][C:2]1[C:3]([F:14])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2

Komponenten

4

Edukt 1

HCID 671234961351570-69-8

Produkt 1

HCID 454803935-Bromo-4-fluoro-1H-indazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 1-(5-Bromo-4-fluoroindazol-1-yl)ethanone (13 mmol) in 10% HCl (40 mL) and methanol (10 mL) was heated at reflux until clear (ca. 1 h). The hot solution was filtered, cooled and pH was neutralized by the addition of NaOH solution (3N). The resultant white precipitate was collected via filtration and the solid was dried in vacuum to give 5-bromo-4-fluoro-1H-indazole.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux until clear (ca. 1 h)
  3. filtrationThe hot solution was filtered
  4. temperaturecooled
  5. additionpH was neutralized by the addition of NaOH solution (3N)
  6. filtrationThe resultant white precipitate was collected via filtration
  7. customthe solid was dried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f75408b8091f4154a649b4731b9006e2
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796256B2

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