N-bromobutanimide → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine

HRID 2401160

Reaktionsgleichung

Reaktionsgleichung von HRID 2401160
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[N:15]=[C:14]([S:16]([CH3:18])=[O:17])[N:13]=[C:12]([NH2:19])[CH:11]=1>CN(C=O)C>[Br:1][C:11]1[C:12]([NH2:19])=[N:13][C:14]([S:16]([CH3:18])=[O:17])=[N:15][C:10]=1[Cl:9]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 15563630HCID 15563630, Verbindung

Produkt 1

HCID 866770165-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amineAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

11.2 g (62.6 mmol) de N-bromosuccinimide were slowly added to a cooled suspension of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 130 ml of DMF. After 50 minutes stirring at room temperature the precipitate was filtered washed with cool DMF, several times with cool water and dried in vacuum. There was obtained 11.4 g (81%) of a white solid.

Aufarbeitung

  1. filtrationwas filtered
  2. washwashed with cool DMF, several times with cool water
  3. customdried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ab2294b0b0e240c9a93440f63ec30081
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796284B2

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