N-bromobutanimide → 5-Bromo-6-chloro-2-methanesulfinylpyrimidin-4-amine
Reaktionsgleichung
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[N:15]=[C:14]([S:16]([CH3:18])=[O:17])[N:13]=[C:12]([NH2:19])[CH:11]=1>CN(C=O)C>[Br:1][C:11]1[C:12]([NH2:19])=[N:13][C:14]([S:16]([CH3:18])=[O:17])=[N:15][C:10]=1[Cl:9]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
11.2 g (62.6 mmol) de N-bromosuccinimide were slowly added to a cooled suspension of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 130 ml of DMF. After 50 minutes stirring at room temperature the precipitate was filtered washed with cool DMF, several times with cool water and dried in vacuum. There was obtained 11.4 g (81%) of a white solid.
Aufarbeitung
- filtrationwas filtered
- washwashed with cool DMF, several times with cool water
- customdried in vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-ab2294b0b0e240c9a93440f63ec30081
- Quelldatensatz
- uspto-grants-2014_08
- Patentnummer
- US08796284B2
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