Hydrochloric Acid → 1-(6-Chloropyrimidin-4-yl)ethan-1-one

HRID 2401189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2401189
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([O:10]CC)=[CH2:9])[N:5]=[CH:4][N:3]=1.Cl>CC(C)=O>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([C:8](=[O:10])[CH3:9])[CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 865947284-Chloro-6-(1-ethoxyvinyl)pyrimidine2×

Produkt 1

HCID 722142471-(6-Chloropyrimidin-4-yl)ethan-1-oneAusbeute 76,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

4-Chloro-6-[1-(ethyloxy)ethenyl]pyrimidine (Intermediate 17, 3.54 g, 19.17 mmol) was dissolved in acetone (177 mL), treated with 2M aqueous hydrochloric acid solution (28.8 mL, 57.5 mmol) and the resulting mixture was stirred at room temperature for 18 hours. The solvent was removed under reduced pressure. The residue was neutralised with aqueous saturated sodium bicarbonate solution and extracted with ethyl acetate (×2). The ethyl acetate layers were combined, dried under magnesium sulfate and evaporated under reduced pressure to give the title compound as a white solid (2.30 g);

Aufarbeitung

  1. customThe solvent was removed under reduced pressure
  2. extractionextracted with ethyl acetate (×2)
  3. customdried under magnesium sulfate
  4. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a7553d8829d3406b8e834eeafe3f7f94
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796283B2

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