Nitric Acid → 4-Chloro-3-nitrophenyl cyclopropyl ketone

HRID 2402348Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2402348
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]2[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[N+:13]([O-])([OH:15])=[O:14]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH:10]2[CH2:11][CH2:12]2)=[O:9])=[CH:6][C:7]=1[N+:13]([O-:15])=[O:14]

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 811484-Chlorophenyl cyclopropyl ketone

Produkt 1

HCID 12682594-Chloro-3-nitrophenyl cyclopropyl ketone

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

Under argon and at −10° C., 20 g (110.7 mmol) of (4-chlorophenyl)(cyclopropyl)methanone were added slowly to 60 ml of concentrated nitric acid. The reaction mixture was then slowly warmed to 5° C. and stirred at this temperature for 6 h. Carefully, the reaction solution was then added with stirring to about 100 ml of ice-water. This resulted in the precipitation of a white solid which was filtered off with suction and washed repeatedly with water. The solid obtained in this manner was then dried under high vacuum. This gave 24.3 g (97% of theory) of the desired product.

Aufarbeitung

  1. additionCarefully, the reaction solution was then added
  2. customThis resulted in the precipitation of a white solid which
  3. filtrationwas filtered off with suction
  4. washwashed repeatedly with water
  5. customThe solid obtained in this manner
  6. customwas then dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-aff21bc8cc554f5f945f66d09358ccf5
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796335B2

Notizen zur Reaktion

Wird geladen…