Phosphorus oxychloride → 2-Chloro-4-phenylquinazoline

HRID 2402490

Reaktionsgleichung

Reaktionsgleichung von HRID 2402490
[C:1]1([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9](=O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:20])=O>>[Cl:20][C:9]1[N:8]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 634302(1H)-Quinazolinone, 4-phenyl-

Produkt 1

HCID 31235822-Chloro-4-phenylquinazoline

Reaktionsbedingungen

Temperatur
105 °C

Versuchsvorschrift

A flask was charged with 4-phenylquinazolin-2(1H)-one (110 g, 0.51 mol) and phosphorus oxychloride (300 mL), and the mixture was stirred at 105° C. for 30 min. The reaction mixture was cooled to rt and slowly poured over an ice/water mixture. The solid was collected by filtration, washed with water (50 mL) and dried under reduced pressure. The product, 2-chloro-4-phenylquinazoline, was isolated as an off-white solid (110 g, 91%).

Aufarbeitung

  1. temperatureThe reaction mixture was cooled to rt
  2. filtrationThe solid was collected by filtration
  3. washwashed with water (50 mL)
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-be8404ec798a4500ac1455fb687fa3b6
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796294B2

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