Hydrochloric Acid → HCID 178511697, Verbindung
Reaktionsgleichung
C(OC(=O)N[C@H]1CC[C@@H](O)CC1)(C)(C)C.[Cl:16]C1C2C(=C(Cl)C(F)=CC=2)C=CN=1.Cl.Cl.[NH2:31][C@@H:32]1[CH2:37][CH2:36][C@H:35]([O:38][C:39]2[CH:40]=[C:41]3[C:46](=[CH:47][C:48]=2Cl)[C:45]([OH:50])=[N:44][CH:43]=[CH:42]3)[CH2:34][CH2:33]1>>[NH2:31][C@@H:32]1[CH2:37][CH2:36][C@H:35]([O:38][C:39]2[C:40]([Cl:16])=[C:41]3[C:46](=[CH:47][CH:48]=2)[C:45](=[O:50])[NH:44][CH:43]=[CH:42]3)[CH2:34][CH2:33]1Komponenten
5
Versuchsvorschrift
Starting from cis-(4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester and 1,5-dichloro-6-fluoro-isoquinoline (9), the title compound was prepared as hydrochloride following the route described for 6-(cis-4-amino-cyclohexyloxy)-7-chloro-isoquinolin-1-ol hydrochloride (10). Rt=1.04 min (Method B). Detected mass: 293.1/295.1 (M+H+).