Triphenylphosphine → HCID 59536867, Verbindung

HRID 2402792Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2402792
[CH3:1][S:2]([CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13])=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClC(Cl)(Cl)Cl>[CH3:1][S:2][CH2:4][CH:5]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]([F:15])([F:14])[F:13]

Komponenten

4

Edukt 2

HCID 11776TriphenylphosphineHCID 59536884tert-Butyl {2-(methylsulphinyl)-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Produkt 1

HCID 59536867HCID 59536867, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

Of the compound from Example 108A, 400 mg (1.14 mmol), and 567 mg (2.16 mmol) of triphenylphosphine, were dissolved in 14 ml of tetrachloromethane. The reaction mixture was stirred overnight at reflux temperature and then freed from the solvent on a rotary evaporator. The residue was purified by preparative HPLC [Method 20]. The product fraction was freed from the solvent on a rotary evaporator. Drying in an HV gave 340 mg (85% of theory) of the title compound.

Aufarbeitung

  1. temperatureat reflux temperature
  2. customfreed from the solvent on a rotary evaporator
  3. customThe residue was purified by preparative HPLC [Method 20]
  4. customThe product fraction was freed from the solvent on a rotary evaporator
  5. customDrying in an HV

Quellen und Nachweise

ORD-Eintrag
ord-4eb2127b3e0b46f28ba85d27af438664
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08796324B2

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