Ethyl 4-amino-1-piperidinecarboxylate → Ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylate

Reaktionsgleichung

Br[CH:2]([CH2:7][CH2:8]Br)[C:3]([O:5][CH3:6])=[O:4].[NH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:13][CH2:12]1>>[CH3:6][O:5][C:3]([CH:2]1[CH2:7][CH2:8][N:10]1[CH:11]1[CH2:12][CH2:13][N:14]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:15][CH2:16]1)=[O:4]

Komponenten

Edukt 2

HCID 100867Ethyl 4-amino-1-piperidinecarboxylate

HCID 296716Methyl 2,4-dibromobutanoate

Produkt 1

HCID 86692756Ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylateAusbeute 50 %

Versuchsvorschrift

The reaction of methyl 2,4-dibromobutanoate 17 with ethyl 4-aminopiperidine-1-carboxylate 18K yielded ethyl 4-(2-(methoxycarbonyl)azetidin-1-yl)piperidine-1-carboxylate as a yellow oil (50%). MS ISP (m/e): 271.3 (100) [(M+H)]+.

Quellen und Nachweise

ORD-Eintrag: ord-4fe7b9c194d24cb0a181376ae00c5b93
Quelldatensatz: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08802665B2

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