6-(4-((Tert-butoxy)carbonyl)piperazin-1-yl)pyridine-3-carboxylic acid → 6-(Piperazin-1-yl)pyridine-3-carboxylic acid dihydrochloride

HRID 2403572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2403572
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>O1CCOCC1>[ClH:23].[ClH:23].[N:11]1([C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Komponenten

4

Edukt 2

HCID 27718236-(4-((Tert-butoxy)carbonyl)piperazin-1-yl)pyridine-3-carboxylic acidHCID 204431481,4-Dioxane hydrochloride

Produkt 1

HCID 866679696-(Piperazin-1-yl)pyridine-3-carboxylic acid dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinic acid (934 mg) was dissolved in dioxane (12 ml), and 4 M hydrogen chloride/dioxane (7 ml) was added thereto, followed by stirring at room temperature overnight. The precipitated solid was collected by filtration to obtain 6-piperazin-1-yl nicotinic acid dihydrochloride (850 mg).

Aufarbeitung

  1. filtrationThe precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-8719bf3edd92439d99020cb7dc727709
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08802679B2

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