3-(Propan-2-yloxy)aniline → (3aR,6aS)-tert-butyl 5-(5-(3-isopropoxyphenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

HRID 240516Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 240516
[C:1]([O:5][C:6]([N:8]1[CH2:12][C@H:11]2[CH2:13][N:14]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([CH:24]=3)[C:21](O)=[O:22])[CH2:15][C@H:10]2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:25]([O:28][C:29]1[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=1)[NH2:32])([CH3:27])[CH3:26]>>[CH:25]([O:28][C:29]1[CH:30]=[C:31]([NH:32][C:21]([C:20]2[CH:24]=[C:16]([N:14]3[CH2:13][C@@H:11]4[CH2:12][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9][C@@H:10]4[CH2:15]3)[CH:17]=[N:18][CH:19]=2)=[O:22])[CH:33]=[CH:34][CH:35]=1)([CH3:27])[CH3:26]

Komponenten

3

Edukt 2

HCID 5732203-(Propan-2-yloxy)anilineHCID 67265367HCID 67265367, Verbindung

Produkt 1

HCID 66917056(3aR,6aS)-tert-butyl 5-(5-(3-isopropoxyphenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Versuchsvorschrift

The product from Example 33B and 3-isopropoxyaniline were processed as described in Example 33C to provide the title compound. MS (APCI) m/z 467 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-c8e1718036114460a57888e1a544f505
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648084B2

Notizen zur Reaktion

Wird geladen…