Chlorosuccinimide → HCID 59756645, Verbindung

HRID 2405751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2405751
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2.[Cl:13]N1C(=O)CCC1=O>CN(C=O)C>[NH2:1][C:2]1[C:3]([Cl:13])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 513420016-Amino-1,2-dihydroisoquinolin-1-one

Produkt 1

HCID 59756645HCID 59756645, VerbindungAusbeute 82,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 0.500 g (3.12 mmol) of 6-amino-2H-isoquinolin-1-one in DMF (30 mL) was added 0.45 g (3.4 mol) of N-chlorosuccinimide. The mixture was stirred at room temperature for 15 h then poured over ice and stirred until all the ice was melted during which time a solid precipitated from solution. The tan solid was collected by filtration, washed with water and dried on the filter pad to provide 0.50 g (82% yield) of the title compound. MS calc. for C9H8ClN2O [M+H]+: 195.63. Found: 195.23.

Aufarbeitung

  1. additionthen poured over ice
  2. customprecipitated from solution
  3. filtrationThe tan solid was collected by filtration
  4. washwashed with water
  5. customdried on the filter pad

Quellen und Nachweise

ORD-Eintrag
ord-58f28356a7134552ad67b463146e57a6
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809326B2

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