Hydrochloric Acid → Amiselimod(MT-1303) hydrochloride

HRID 2406023Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2406023
C(OC(=O)[NH:7][C:8]1([CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[C:20]([C:32]([F:35])([F:34])[F:33])[CH:19]=2)[CH2:13][O:12]C(C)(C)[O:10][CH2:9]1)(C)(C)C.[ClH:37]>C(O)C>[ClH:37].[NH2:7][C:8]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[C:20]([C:32]([F:33])([F:34])[F:35])[CH:19]=1)([CH2:9][OH:10])[CH2:13][OH:12]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57704611HCID 57704611, Verbindung

Produkt 1

HCID 67418070Amiselimod(MT-1303) hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Compound 1-2 (640 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (3 ml) was added, and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (492 mg) as white powder.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-577b6134ed3a46919e97c51dd84d2667
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809304B2

Notizen zur Reaktion

Wird geladen…