Trifluoroacetic acid → 4-Amino-1-methylpiperazin-2-one 2,2,2-trifluoroacetate

HRID 240723Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 240723
C(OC(=O)[NH:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 71294329(4-Methyl-3-oxo-piperazin-1-yl)-carbamic acid t-butyl ester

Produkt 1

HCID 712943164-Amino-1-methylpiperazin-2-one 2,2,2-trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

(4-Methyl-3-oxo-piperazin-1-yl)-carbamic acid t-butyl ester (67 mg, 292 μmol) was at 0° C. combined with dichloromethane (2 mL) and trifluoroacetic acid (1 mL) to give a light yellow solution. The reaction mixture was stirred for 2 h at 0° C. and subsequently concentrated in vacuo to give the title compound as yellow oil, which was used without further purification in the next step.

Aufarbeitung

  1. customwas at 0° C.
  2. customto give a light yellow solution
  3. concentrationsubsequently concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8ad12926f3fc4fe9896de6257f42e62d
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648099B2

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