Sodium Hydroxide → 2,3-dihydro-2,2-diMethylbenzofuran-5-carboxylic acid

HRID 2407474Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2407474
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:15][C:14]([CH3:17])([CH3:16])[CH2:13][C:12]=2[CH:18]=1)=[O:7])C>>[CH3:16][C:14]1([CH3:17])[CH2:13][C:12]2[CH:18]=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[CH:10][C:11]=2[O:15]1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 59509487HCID 59509487, Verbindung

Produkt 1

HCID 148382312,3-dihydro-2,2-diMethylbenzofuran-5-carboxylic acid

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

An aqueous solution (10 mL) of sodium hydroxide (0.78 g, 0.0195 mol) is added to an ethanolic solution (30 mL) of 2,2-dimethyl-2,3-dihydrobenzofuran-5-carboxylic acid ethyl ester (3.9 g, 0.018 mol). The reaction mixture is heated at 75° C. for four and an half hours. Ethanol is removed under reduced pressure. Demineralized water is added to the residue and pH is brought to ˜3 with 1 N HCl. Solid thus obtained is filtered, washed with demineralized water and dried under reduced pressure to give 2,2-dimethyl-2,3-dihydrobenzofuran-5-carboxylic acid.

Aufarbeitung

  1. customEthanol is removed under reduced pressure
  2. additionDemineralized water is added to the residue and pH
  3. customSolid thus obtained
  4. filtrationis filtered
  5. washwashed with demineralized water
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-a00a28ebb39b4582afdeb63a8db86b20
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809539B2

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