[5-(2-PYRIDINYL)-2-THIENYL]METHANOL → 5-(Pyridin-2-yl)thiophene-2-carbaldehyde

HRID 2407664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2407664
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH2:12][OH:13])=[CH:9][CH:8]=1>O1CCCC1.[O-2].[O-2].[Mn+4]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=1

Komponenten

4

Edukt 1

HCID 2776202[5-(2-PYRIDINYL)-2-THIENYL]METHANOL

Produkt 1

HCID 6051275-(Pyridin-2-yl)thiophene-2-carbaldehydeAusbeute 8.307,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of (5-(pyridin-2-yl)thien-2-yl) methanol (0.100 g) and manganese dioxide (0.136 g) in tetrahydrofuran (3.5 mL) was refluxed overnight. The mixture was cooled to room temperature and the solids were filtered. The filtrate was concentrated and the residue was triturated (hexane:diethyl ether=1:1) to obtain the title compound (8.22 g) having the following physical data.

Aufarbeitung

  1. filtrationthe solids were filtered
  2. concentrationThe filtrate was concentrated
  3. customthe residue was triturated (hexane:diethyl ether=1:1)

Quellen und Nachweise

ORD-Eintrag
ord-27bbdf48b6e240269cf7de43153fb030
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809538B2

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