Hydrochloric Acid → HCID 66989793, Verbindung

HRID 2407733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2407733
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[O:14])[CH:3]=1.[ClH:30]>ClCCl.CO>[ClH:30].[ClH:30].[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[O:14])[CH:3]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 58504102HCID 58504102, Verbindung

Produkt 1

HCID 66989793HCID 66989793, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The compound prepared in Example 225 (0.603 g) was suspended in dichloromethane (30 mL) and methanol (10 mL). Hydrogen chloride solution (4 mol/L in 1,4-dioxane) (10.0 mL) was added and the reaction mixture stirred at room temperature for 6 hours. The reaction mixture was concentrated under reduced pressure to afford the title compound (0.547 g), which was used without further purification, possessing the following physical data.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1ad2197bee6440e3b43e77ca7c635dfe
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809538B2

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