Potassium Carbonate → HCID 58504138, Verbindung
Reaktionsgleichung
[CH3:1][O:2][CH:3]([O:40][CH3:41])[CH2:4][N:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18](=[O:39])[CH2:19][CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:27][C:28]2[S:32][C:31]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=3)=[N:30][CH:29]=2)[CH2:23][CH2:22]1)[C:6](=O)[C:7]([O:9][CH3:10])=[O:8].C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:1][O:2][CH:3]([O:40][CH3:41])[CH2:4][N:5]1[C:12]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:18](=[O:39])[C:19]([CH2:20][CH:21]2[CH2:22][CH2:23][N:24]([CH2:27][C:28]3[S:32][C:31]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][N:34]=4)=[N:30][CH:29]=3)[CH2:25][CH2:26]2)=[C:6]1[C:7]([O:9][CH3:10])=[O:8]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The compound prepared in Example 324 (0.390 g) was suspended in methanol (7 mL) and potassium carbonate (0.093 g) added. The reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to afford the crude material, which was partitioned between ethyl acetate and water. The organics were washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude product, which was purified by flash column chromatography (eluant: 5% (9:1 methanol/concentrated ammonium hydroxide)/ethyl acetate) to furnish the title compound (0.340 g) having the following physical properties.