HCID 58504050, Verbindung → 1-(2-pyridin-2-yl-1,3-thiazol-5-yl)ethanone

HRID 2407797Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2407797
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][C:9]([CH:12]([OH:14])[CH3:13])=[CH:10][N:11]=1>ClCCl.[O-2].[Mn+4].[O-2]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][C:9]([C:12](=[O:14])[CH3:13])=[CH:10][N:11]=1

Komponenten

4

Edukt 1

HCID 58504050HCID 58504050, Verbindung

Produkt 1

HCID 27682031-(2-pyridin-2-yl-1,3-thiazol-5-yl)ethanoneAusbeute 94,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The compound prepared in Example 357 (2.5 g) was dissolved in 80 mL of dichloromethane and manganese (IV) oxide (21 g) was added stirred overnight at room temperature. The reaction mixture was filtered through a plug of Celite (trade mark), washed with dichloromethane, and concentrated under reduced pressure to afford the title compound (2.35 g) having the following physical data. 1H NMR (CDCl3): δ 8.64 (d, J=4.5 Hz, 1H), 8.39 (s, 1H), 8.22 (d, J=7.9 Hz, 1H), 7.83 (m, 1H), 7.39 (m, 1H), 2.62 (s, 3H).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a plug of Celite (trade mark)
  2. washwashed with dichloromethane
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e57a1c6a15e548039db900719452fcdb
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08809538B2

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