Triethylamine → 3-(Trifluoromethyl)isoxazole

HRID 240809

Reaktionsgleichung

Reaktionsgleichung von HRID 240809
C1(N=C=O)C=CC(N=C=O)=CC=1.C(N(CC)CC)C.COC1C=C[C:25]([C:28]#[C:29][C:30]([F:33])([F:32])[F:31])=CC=1.COC(=O)CCC[N+:40]([O-])=[O:41]>C1(C)C=CC=CC=1>[F:31][C:30]([C:29]1[CH:28]=[CH:25][O:41][N:40]=1)([F:33])[F:32]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 25604Methyl 4-nitrobutyrateHCID 610091,4-DiisocyanatobenzeneHCID 11333117Benzene, 1-methoxy-4-(3,3,3-trifluoro-1-propynyl)-

Produkt 1

HCID 137394013-(Trifluoromethyl)isoxazoleAusbeute 56,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

1,4-Phenylene diisocyanate (597.1 mg, 3.73 mol) and triethylamine (780 μL, 5.60 mmol) were added to a solution of 1-methoxy-4-trifluoropropynylbenzene (373.2 mg, 1.86 mmol) and 4-nitrobutanoic acid methyl ester (441.5 mg, 2.80 mmol) in toluene (10 mL). Using a microwave reactor, the obtained mixture was stirred at 150° C. for 2 hours. The reaction solution was filtered with celite, and the solvent was then distilled away. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain a trifluoromethyl isoxazole compound (144.0 mg, yield: 25%).

Aufarbeitung

  1. filtrationThe reaction solution was filtered with celite
  2. distillationthe solvent was then distilled away
  3. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-2e26deebd655408b90e6dec23afdcba7
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08648103B2

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