Potassium Carbonate → 2-chloro-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzaldehyde

A mixture of 2-chloro-4-fluorobenzaldehyde (5.0 g, 31.5 mmol), 3-(trifluoromethyl)-pyrazole (4.28 g, 31.5 mmol) and potassium carbonate (6.53 g, 47.3 mmol) in anhydrous N,N-dimethylformamide (40 mL) was stirred for 2 h at 110° C. The reaction mixture was cooled to 0° C., poured into ice water (500 mL) and stirred for 15 min. The precipitate formed was filtered and dried under reduced pressure to afford the title compound (8.1 g), which was used without further purification.

1. temperatureThe reaction mixture was cooled to 0° C.
2. stirringstirred for 15 min
3. customThe precipitate formed
4. filtrationwas filtered
5. customdried under reduced pressure

ORD-Eintrag

ord-cafc0bb35846459c968d50771d3107c3

Quelldatensatz

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08815772B2