Quinoline-2-boronic acid → HCID 86720130, Verbindung
Reaktionsgleichung
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[N:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1B(O)O>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([O:25][C:28]5[CH:29]=[CH:30][C:31]6[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=6)[N:27]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1Komponenten
3
Versuchsvorschrift
The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and quinoline-2-boronic acid following a procedure analogous to that described for Intermediate 6. LC (method 4): tR=0.86 min; Mass spectrum (ESI+): m/z=486 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-989c43af926242ee9f80ed44a85fd6ca
- Quelldatensatz
- uspto-grants-2014_08