Ethyl 4-cyano-2,2-bis(4-fluorophenyl)butanoate → 3,3-Bis(4-fluorophenyl)piperidin-2-one

Beteiligte Stoffe

Reaktionsschritte

The product from Example 23A (560 mg, 1.700 mmol) as a solution in 7 M ammonia/methanol (20 mL) was added to solvent-washed Raney®-nickel (2800 mg, 47.7 mmol) in a 250 mL stainless steel pressure bottle and stirred at room temperature for 24 hours under hydrogen (30 pounds per square inch). The mixture was filtered through a nylon membrane and was concentrated. The residue was dissolved in methanol/dichloromethane (1:1), filtered and concentrated to give a solid which was slurried in methanol, filtered and dried to give the title compound. MS (DCI) m/z 288 (M+H)+.

Herkunft & Nachweise