tert-Butyl (4-hydroxynaphthalen-1-yl)carbamate → Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)naphthalen-1-ylcarbamate

HRID 2409260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2409260
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:4][CH:3]=1.[NH2:20][C:21]1[C:26]([N+:27]([O-:29])=[O:28])=[C:25](OC2C=CC(NC(=O)OC(C)(C)C)=C(F)C=2)[CH:24]=[CH:23][N:22]=1>>[C:15]([O:14][C:13](=[O:19])[NH:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([O:1][C:25]2[CH:24]=[CH:23][N:22]=[C:21]([NH2:20])[C:26]=2[N+:27]([O-:29])=[O:28])=[CH:3][CH:4]=1)([CH3:16])([CH3:18])[CH3:17]

Komponenten

3

Edukt 2

HCID 10923237tert-Butyl (4-hydroxynaphthalen-1-yl)carbamateHCID 44185771Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)-2-fluorophenylcarbamate

Produkt 1

HCID 44186165Tert-butyl 4-(2-amino-3-nitropyridin-4-yloxy)naphthalen-1-ylcarbamate

Versuchsvorschrift

The title compound was prepared from tert-butyl 4-hydroxynaphthalen-1-ylcarbamate (Regan, J. et al, J. Med. Chem., 2002, Vol. 45, No. 14, p. 2994) (3.9 g, 15 mmol) by the same method as described for compound (3a).

Quellen und Nachweise

ORD-Eintrag
ord-b4daed26d88540f182e20b8370fae196
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08815896B2

Notizen zur Reaktion

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