Diclofensine → Tartrate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Diclofensine	HCID 68871	—
Edukt	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt	HCID 117729042	—
Produkt	Tartrate	HCID 119400	—
Produkt	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-Tartrate Salt	HCID 117729042	—

Reaktionsschritte

The L-tartrate of the (−)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline was prepared using (−)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline following similar steps described for the synthesis of the (+)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline, L-tartrate salt ([α]24D−6.0° (c 0.10, methanol)).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08815894B2
Quelldatensatz	uspto-grants-2014_08
ORD ID	ord-5a9cc3bb05e64f1888764746bdca19c0
Quellennotiz	uspto-grants-2014_08