1-benzyl-2-nitro-1H-imidazole → 1-Benzyl-1H-imidazol-2-ylamine
Reaktionsgleichung
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[N+:13]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].CO>[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[NH2:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A suspension of 1-benzyl-2-nitro-1H-imidazole (Step 160.2) (410 mg, 1.16 mmol) and Raney nickel (40 mg) in MeOH (10 mL) was stirred for 3 h at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 345 mg of the title compound as a brown solid: ESI-MS: 173.9 [M+H]+; tR=2.02 min (System 1).
Aufarbeitung
- filtrationThe reaction mixture was filtered through a pad of celite
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-c550dcd2585a4bfea8335e7dd25f288f
- Quelldatensatz
- uspto-grants-2014_08
- Patentnummer
- US08815901B2
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