3-Chloroaniline → HCID 86707780, Verbindung

HRID 2410136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2410136
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])O)=[O:5])[CH3:2].[Cl:25][C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29]>C(Cl)Cl.O>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])[NH:29][C:28]1[CH:30]=[CH:31][CH:32]=[C:26]([Cl:25])[CH:27]=1)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 79323-ChloroanilineHCID 86707752HCID 86707752, Verbindung

Produkt 1

HCID 86707780HCID 86707780, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21908982Water methylene chlorideLösungsmittel

Versuchsvorschrift

The title compound was prepared in analogy to the procedure described for step E2 with the intermediate C and the 3-chloroaniline. The reaction mixture was diluted in DCM/water and the phases were separated. The organic phase was dried (Na2SO4) and concentrated. The product was purified by flash chromatography (heptane/EtOAc, 9:1) to give the title compound. tR: 1.47 min (LC-MS 2); ESI-MS: 524.0/526.0/528.2 [M+H]+ (LC-MS 2).

Aufarbeitung

  1. customThe title compound was prepared in analogy to the procedure
  2. customthe phases were separated
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated
  5. customThe product was purified by flash chromatography (heptane/EtOAc, 9:1)

Quellen und Nachweise

ORD-Eintrag
ord-f35b6beeccf741868f98740febbe1eaf
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08815926B2

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