1-Bromo-2-methylpropane → HCID 58293149, Verbindung

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Reaktionsgleichung

[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH2:9](Br)[CH:10]([CH3:12])[CH3:11].FC(F)(F)S(OCC(F)(F)F)(=O)=O>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:9][CH:10]([CH3:12])[CH3:11])[CH:3]=1

Komponenten

Edukt 3

HCID 65551-Bromo-2-methylpropane

HCID 97433-Fluorophenol

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

Produkt 1

HCID 58293149HCID 58293149, Verbindung

Versuchsvorschrift

The title compound was prepared according to the procedure described in Step 7 of EXAMPLE 7 using 3-fluorophenol and isobutyl bromide instead of methyl 4-[(4-{2-[(4-hydroxy-1,2-benzisoxazol-3-yl)oxy]ethyl}piperidin-1-yl)methyl]tetrahydro-2H-pyran-4-carboxylate and 2,2,2-trifluoroethyl trifluoromethanesulfonate.

Quellen und Nachweise

ORD-Eintrag: ord-a57818a14e2c408497db3e028e109627
Quelldatensatz: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08816090B2

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