3-Chloropropanesulphonyl chloride → methyl (S)-4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)ethyl]benzoate

Reaktionsgleichung

[NH2:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3]

Komponenten

Edukt 2

HCID 154103-Chloropropanesulphonyl chloride

HCID 17751895Methyl 4-((1S)-1-aminoethyl)benzoate

Produkt 1

HCID 71261170methyl (S)-4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)ethyl]benzoate

Versuchsvorschrift

Using methyl (S)-4-(1-aminoethyl)benzoate (0.61 g) and 3-chloropropane-1-sulfonyl chloride (0.54 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (0.90 g) was obtained.

Aufarbeitung

customby the reaction and treatment in the same manner
customas in Preparation Example 17

Quellen und Nachweise

ORD-Eintrag: ord-70fc857922274c519bb0849776f49c26
Quelldatensatz: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08816079B2

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