N,N-bis(2-chloroethyl)-p-toluenesulphonamide → 1-(4-Methyl-2-trifluoromethylphenyl)piperazine

HRID 2411228Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411228
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.Cl[CH2:14][CH2:15][N:16]([CH2:27][CH2:28]Cl)S(C1C=CC(C)=CC=1)(=O)=O>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:28][CH2:27][NH:16][CH2:15][CH2:14]2)=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

Komponenten

3

Edukt 2

HCID 96039N,N-bis(2-chloroethyl)-p-toluenesulphonamideHCID 27377104-Methyl-2-(trifluoromethyl)aniline

Produkt 1

HCID 213638351-(4-Methyl-2-trifluoromethylphenyl)piperazineAusbeute 26,4 %

Versuchsvorschrift

Using 4-methyl-2-trifluoromethylphenylamine (1 g) and N,N-bis(2-chloroethyl)-p-toluenesulfonamide (1.69 g) and by the reaction and treatment in the same manner as in Preparation Example 95, the title compound (368 mg) was obtained.

Aufarbeitung

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 95

Quellen und Nachweise

ORD-Eintrag
ord-7ae19ebd6fbd4d77aceb3d0a2b2ca217
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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