1-(2,4-Xylyl)piperazine → (4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411281Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411281
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1)([O-])=O.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:26][CH2:27]2)=[O:10])=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1

Komponenten

3

Edukt 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27827374-Nitro-2-(trifluoromethyl)benzoic acid

Produkt 1

HCID 86676758(4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneAusbeute 106,3 %

Versuchsvorschrift

Using 4-nitro-2-trifluoromethylbenzoic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (403 mg) and by the reaction and treatment in the same manner as in Preparation Example 148, the title compound (850 mg) was obtained.

Aufarbeitung

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 148

Quellen und Nachweise

ORD-Eintrag
ord-a0489e466a9349c3a9e8ff44c57850b1
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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