4-Bromo-2-cyanobenzoic acid → 5-Bromo-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile

HRID 2411308Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411308
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([C:11]#[N:12])[CH:3]=1.[CH3:13][C:14]1[C:15]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:16][C:17]([CH3:21])=[C:18]([CH3:20])[CH:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:15]3[C:14]([CH3:13])=[CH:19][C:18]([CH3:20])=[C:17]([CH3:21])[N:16]=3)[CH2:23][CH2:24]2)=[O:8])=[C:4]([CH:3]=1)[C:11]#[N:12]

Komponenten

3

Edukt 2

HCID 584845854-Bromo-2-cyanobenzoic acidHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

Produkt 1

HCID 712521745-Bromo-2-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrileAusbeute 87,9 %

Versuchsvorschrift

Using 4-bromo-2-cyanobenzoic acid (3.84 g) described in Preparation Example 76 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (3.66 g) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (6.17 g) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111

Quellen und Nachweise

ORD-Eintrag
ord-40e72af43e344d2ebe3ba2aeb4fbf94e
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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