6-Fluoro-4-methylpyridine-3-carboxylic acid → [4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone

HRID 2411314

Reaktionsgleichung

Reaktionsgleichung von HRID 2411314
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[C:16]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[C:16]([N:24]3[CH2:25][CH2:26][N:27]([C:6]([C:5]4[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=4[CH3:11])=[O:8])[CH2:28][CH2:29]3)=[N:17][CH:18]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:20]=2)[CH2:13][CH2:14]1

Komponenten

3

Edukt 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 584847011-(3,5-Dicyclopropylpyridin-2-yl)piperazine

Produkt 1

HCID 58484583[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanoneAusbeute 85,5 %

Versuchsvorschrift

Using 6-fluoro-4-methylnicotinic acid (0.60 g) and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (0.92 g) described in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.23 g) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 88 and by the reaction and treatment in the same manner as in Preparation Example 111

Quellen und Nachweise

ORD-Eintrag
ord-fa192ea190e34de99eac0f8f12d02be3
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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