6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 58484588, Verbindung

HRID 2411315Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411315
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:25][CH2:26][N:27]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:28][CH2:29]2)[CH2:13][CH2:14]1

Komponenten

3

Edukt 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 67381204HCID 67381204, Verbindung

Produkt 1

HCID 58484588HCID 58484588, VerbindungAusbeute 103,8 %

Versuchsvorschrift

Using 6-fluoro-4-methylnicotinic acid (386 mg) and 1-(2,4-dicyclopropylphenyl)piperazine (650 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (980 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118

Quellen und Nachweise

ORD-Eintrag
ord-2857f953ab9e4c88a45d7b07ef7bb419
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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