6-Bromonicotinic acid → 2-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile

HRID 2411320Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411320
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[C:11]([C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1)#[N:12]>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[N:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[C:11]#[N:12])[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

Komponenten

3

Edukt 2

HCID 2389326-Bromonicotinic acidHCID 712522894-(3-Cyano-5-methylpyridin-2-yl)piperazine

Produkt 1

HCID 866767642-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrileAusbeute 79,2 %

Versuchsvorschrift

Using 6-bromonicotinic acid (303 mg) and 4-(3-cyano-5-methylpyridin-2-yl)piperazine (303 mg) described in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (458 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111

Quellen und Nachweise

ORD-Eintrag
ord-7eac7b0eb0344ceead57a10fd8a1d035
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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