1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 86676765, Verbindung

HRID 2411355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411355
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=3)[CH2:21][CH2:22]2)=[O:8])=[C:9]([CH3:11])[CH:10]=1

Komponenten

3

Edukt 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 722121586-Bromo-4-methyl-3-pyridinecarboxylic acid

Produkt 1

HCID 86676765HCID 86676765, VerbindungAusbeute 97,7 %

Versuchsvorschrift

Using 6-bromo-4-methylnicotinic acid (500 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (443 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (880 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111

Quellen und Nachweise

ORD-Eintrag
ord-e09ec244a812476aa832513335e741b7
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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