5-Bromopyrazine-2-carboxylic acid → HCID 86676767, Verbindung

HRID 2411359Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411359
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

Produkt 1

HCID 86676767HCID 86676767, VerbindungAusbeute 69,5 %

Versuchsvorschrift

Using 5-bromopyrazine-2-carboxylic acid (203 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (191 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (261 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

Quellen und Nachweise

ORD-Eintrag
ord-ebbee38ada434d988d5ef2b3a423fe0b
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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