5-Bromopyrazine-2-carboxylic acid → HCID 86676769, Verbindung

HRID 2411370Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411370
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:10])=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Produkt 1

HCID 86676769HCID 86676769, VerbindungAusbeute 65,6 %

Versuchsvorschrift

Using 5-bromopyrazine-2-carboxylic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.07 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.3 g) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118

Quellen und Nachweise

ORD-Eintrag
ord-b7b2fca0d1164dc8ab30fd4099a47bfa
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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