4-(1,1-Dioxo-1,2-thiazolidin-2-yl)-2-methylbenzoic acid → [4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl][4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411563Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411563
[O:1]=[S:2]1(=[O:17])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([CH3:16])[CH:8]=1.[CH3:18][C:19]1[C:20]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[N:21][CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:24]=1>>[O:17]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:32]2[CH2:33][CH2:34][N:29]([C:20]3[C:19]([CH3:18])=[CH:24][C:23]([C:25]([F:28])([F:26])[F:27])=[CH:22][N:21]=3)[CH2:30][CH2:31]2)=[O:13])=[C:9]([CH3:16])[CH:8]=1

Komponenten

3

Edukt 2

HCID 545952974-(1,1-Dioxo-1,2-thiazolidin-2-yl)-2-methylbenzoic acidHCID 584847291-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine

Produkt 1

HCID 71252735[4-(1,1-Dioxo-1lambda6-isothiazolidin-2-yl)-2-methylphenyl][4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]methanoneAusbeute 47,7 %

Versuchsvorschrift

Using 4-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylbenzoic acid (255 mg) described in Preparation Example 29 and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (245 mg) described in Preparation Example 84 and by the reaction and treatment in the same manner as in Example 87, the title compound (230 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 84 and by the reaction and treatment in the same manner as in Example 87

Quellen und Nachweise

ORD-Eintrag
ord-4c7587203ae04dabb0b0137ae69deb82
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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