HCID 67381204, Verbindung → [4-(2,4-Dicyclopropylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanone

HRID 2411607Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411607
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=O)=[CH:9][N:8]=1.[CH:19]1([C:22]2[CH:27]=[C:26]([CH:28]3[CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH2:21][CH2:20]1>>[CH:19]1([C:22]2[CH:27]=[C:26]([CH:28]3[CH2:30][CH2:29]3)[CH:25]=[CH:24][C:23]=2[N:31]2[CH2:32][CH2:33][N:34]([C:11]([C:10]3[CH:9]=[N:8][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:17][CH:16]=3)=[O:13])[CH2:35][CH2:36]2)[CH2:20][CH2:21]1

Komponenten

3

Edukt 2

HCID 67381204HCID 67381204, VerbindungHCID 71251937Ethyl 6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)nicotinate

Produkt 1

HCID 71252667[4-(2,4-Dicyclopropylphenyl)piperazin-1-yl][6-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)pyridin-3-yl]methanoneAusbeute 72,4 %

Versuchsvorschrift

Using ethyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)nicotinate (300 mg) described in Preparation Example 25 and 1-(2,4-dicyclopropylphenyl)piperazine (296 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Example 109, the title compound (375 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Example 109

Quellen und Nachweise

ORD-Eintrag
ord-2f2377f3e4c54b60ba47d1d0645a969b
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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