1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71252033, Verbindung

HRID 2411612Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411612
[O:1]=[S:2]1(=[O:18])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=O)=[C:9]([CH3:17])[N:8]=1.[CH3:19][C:20]1[C:21]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1>>[CH3:19][C:20]1[C:21]([N:27]2[CH2:28][CH2:29][N:30]([C:11]([C:10]3[C:9]([CH3:17])=[N:8][C:7]([N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:18])=[CH:16][CH:15]=3)=[O:13])[CH2:31][CH2:32]2)=[N:22][CH:23]=[C:24]([CH3:26])[CH:25]=1

Komponenten

3

Edukt 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 71252256HCID 71252256, Verbindung

Produkt 1

HCID 71252033HCID 71252033, VerbindungAusbeute 67,2 %

Versuchsvorschrift

Using methyl 6-(1,1-dioxo-1λ6-isothiazolidin-2-yl)-2-methylnicotinate (220 mg) described in Preparation Example 37 and 1-(3,5-dimethylpyridin-2-yl)piperazine (186 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109, the title compound (235 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 109

Quellen und Nachweise

ORD-Eintrag
ord-200a0e8bc4e949c3901168e8c3121671
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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