2-Pyrrolidone → 1-{3-Fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one

HRID 2411678Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2411678
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[C:24]([CH3:30])[N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:10]([F:31])[CH:9]=1>>[F:31][C:10]1[CH:9]=[C:8]([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:13]=[CH:12][C:11]=1[C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[C:24]([CH3:30])[N:23]=2)[CH2:20][CH2:21]1)=[O:15]

Komponenten

3

Edukt 2

HCID 120252-PyrrolidoneHCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Produkt 1

HCID 712525421-{3-Fluoro-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-oneAusbeute 89,7 %

Versuchsvorschrift

Using pyrrolidin-2-one (94 mg) and (4-bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (406 mg) described in Preparation Example 128 and by the reaction and treatment in the same manner as in Example 1, the title compound (368 mg) was obtained.

Aufarbeitung

  1. customdescribed in Preparation Example 128 and by the reaction and treatment in the same manner as in Example 1

Quellen und Nachweise

ORD-Eintrag
ord-8c8f2456fb2748f9bfcd3ae348c36f7e
Quelldatensatz
uspto-grants-2014_08
Patentnummer
US08816079B2

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